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First evidence of Anaplasma infection in Crete, Greece. Report of six human cases

2009-01-01, Chochlakis, Dimosthenis, Psaroulaki, Anna, Kokkini, Sofia, Kostanatis, S., Arkalati, E., Karagrannaki, E., Tsioutis, Constantinos, Tselentis, Yiannis J., Gikas, Achilleas I.

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Streptomyces pneumonia in an immunocompetent patient: a case report and literature review

2007-12-01, Kofteridis, Diamantis P., Maraki, Sofia, Scoulica, Efstathia V., Tsioutis, Constantinos, Maltezakis, George, Gikas, Achilleas I.

We describe a case of Streptomyces lanatus pneumonia in an immunocompetent 52-year-old woman. Bronchoalveolar lavage culture grew Streptomyces, which was identified by 16S rRNA sequencing. The infection resolved completely after successful treatment with doxycycline for 6 months. We also review the literature on human invasive Streptomyces infections.

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Surveillance of surgical site infections at a tertiary care hospital in Greece: Incidence, risk factors, microbiology, and impact

2008-12-01, Roumbelaki, Maria, Kritsotakis, Evangelos I., Tsioutis, Constantinos, Tzilepi, Penelope, Gikas, Achilleas I.

Background: In this first attempt to implement a standardized surveillance system of surgical site infections (SSI) in a Greek hospital, our objective was to identify areas for improvement by comparing main epidemiologic and microbiologic features of SSI with international data. Methods: The National Nosocomial Infections Surveillance (NNIS) system protocols were employed to prospectively collect data for patients in 8 surgical wards who underwent surgery during a 9-month period. SSI rates were benchmarked with international data using standardized infection ratios. Risk factors were evaluated by multivariate logistic regression. Results: A total of 129 SSI was identified in 2420 operations (5.3%), of which 47.3% developed after discharge. SSI rates were higher for 2 of 20 operation categories compared with Spanish and Italian data and for 12 of 20 categories compared with NNIS data. Gram-positive microorganisms accounted for 52.1% of SSI isolates, and Enterococci were predominant. Alarming resistance patterns for Enterococcus faecium and Acinetobacter baumannii were recorded. Potentially modifiable risk factors for SSI included multiple procedures, extended duration of operation, and antibiotic prophylaxis. SSI was associated with prolongation of postoperative stay but not with mortality. Conclusion: Comparisons of surveillance data in our hospital with international benchmarks provided useful information for infection control interventions to reduce the incidence of SSI.

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Murine typhus in children: Clinical and laboratory features from 41 cases in Crete, Greece

2009-01-01, Gikas, Achilleas I., Kokkini, Sofia, Tsioutis, Constantinos, Athenessopoulos, D., Balomenaki, Evaggelia, Blasak, S., Matheou, C., Tselentis, Yiannis J., Psaroulaki, Anna