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Stress alleviation strategy in cancer treatment: Insights from a mathematical model

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cris.virtual.departmentEuropean University Cyprus
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cris.virtualsource.department10206332-9e5a-48bb-b909-42741676cd6d
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dc.contributor.authorPapageorgis, Panagiotis
dc.contributor.authorMpekris, Fotios
dc.contributor.authorVoutouri, Chrysovalantis
dc.contributor.authorStylianopoulos, Triantafyllos
dc.date.accessioned2023-09-18T14:18:19Z
dc.date.available2023-09-18T14:18:19Z
dc.date.issued1/12/2018
dc.description.abstractTumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels—while nourishing the tumor—are usually leaky and tortuous, which further decreases perfusion. Consequently, vessel leakiness together with vessel compression causes a uniformly elevated interstitial fluid pressure that hinder drug delivery and compromise therapeutic outcomes. To enhance treatment efficacy, stress alleviation and vascular normalization strategies have been developed to improve tumor perfusion and drug delivery. Stress alleviation strategy aim to decrease solid stress levels and reopen compressed blood vessels leading to improve perfusion and drug delivery. On the other hand, vascular normalization strategy aims to restore the abnormalities in tumor vasculature by decreasing vessel leakiness and thus enhance drug efficacy. Here, we employed a mathematical model to study the stress alleviation strategy using published experimental data and performing new experiments in mice bearing breast tumors. Specifically, we accounted for variations in tumor hydraulic conductivity, elastic modulus and swelling related to changes in extracellular matrix components induced by the anti-fibrotic and stress alleviating drug, tranilast. We showed that alleviation of mechanical stresses in tumors reduces the tumor interstitial fluid pressure to normal levels and increases the functionality of the tumor vasculature resulted in improved drug delivery and treatment outcome. Finally, we used model predictions to show that vascular normalization can be combined with stress alleviation to further improve therapeutic outcomes.
dc.identifier.doi10.1002/zamm.201700270
dc.identifier.eid2-s2.0-85045299569
dc.identifier.issn442267
dc.identifier.otherhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045299569&origin=inward
dc.identifier.otherhttps://repo.euc.ac.cy/handle/123456789/1777
dc.identifier.scopus85045299569
dc.identifier.urihttps://plemochoe.euc.ac.cy/handle/2000/2083
dc.relation.departmentDepartment of Life Sciences
dc.relation.facultySchool of Sciences
dc.relation.ispartofZAMM Zeitschrift fur Angewandte Mathematik und Mechanik
dc.rights.openaccess0
dc.titleStress alleviation strategy in cancer treatment: Insights from a mathematical model
dc.typetext::conference output::conference proceedings::conference paper
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.volume98
oairecerif.author.affiliationEuropean University Cyprus
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